Enables chromatin binding activity and ubiquitin-protein transferase activity. Involved in protein autoubiquitination; protein monoubiquitination; and regulation of DNA replication. Located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for OBI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OBI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OBI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:78,477,868–78,478,863 | 180.7 kb | Distal (>10kb) Multiome | 80 | |
| chr13:78,496,889–78,498,356 | 161.3 kb | Distal (>10kb) Multiome | 197 | |
| chr13:78,586,435–78,587,075 | 72.3 kb | Distal (>10kb) Multiome | 145 | |
| chr13:78,595,488–78,596,692 | 63.0 kb | Distal (>10kb) Multiome | 312 | |
| chr13:78,602,275–78,603,984 | 55.6 kb | Distal (>10kb) Multiome | 557 | |
| chr13:78,606,929–78,609,079 | 51.5 kb | Distal (>10kb) Multiome | 288 | |
| chr13:78,649,717–78,650,639 | 8.5 kb | Proximal (<10kb) | 93 | |
| chr13:78,657,795–78,659,429 | 113 bp | At TSS Multiome | 895 | |
| chr13:78,660,113–78,660,600 | 958 bp | At TSS | 210 | |
| chr13:78,663,640–78,665,282 | 5.3 kb | Proximal (<10kb) Multiome | 278 | |
| chr13:78,880,832–78,881,949 | 222.1 kb | Distal (>10kb) Multiome | 95 |
Genomic view of the OBI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.