Transcription factors with Perturb-seq knockdown data for OAF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OAF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OAF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:120,013,169–120,013,755 | 197.5 kb | Distal (>10kb) Multiome | 219 | |
| chr11:120,057,897–120,058,380 | 152.9 kb | Distal (>10kb) Multiome | 90 | |
| chr11:120,168,771–120,169,627 | 41.8 kb | Distal (>10kb) Multiome | 478 | |
| chr11:120,210,679–120,211,521 | 119 bp | At TSS Multiome | 606 | |
| chr11:120,236,598–120,237,182 | 25.8 kb | Distal (>10kb) Multiome | 249 | |
| chr11:120,255,150–120,255,776 | 44.4 kb | Distal (>10kb) Multiome | 143 | |
| chr11:120,324,948–120,325,789 | 114.3 kb | Distal (>10kb) Multiome | 665 | |
| chr11:120,335,703–120,337,153 | 125.3 kb | Distal (>10kb) Multiome | 976 |
Genomic view of the OAF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.