NYNRIN
NYN domain and retroviral integrase containing | CGIN1, FLJ11811, KIAA1305

Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be involved in DNA integration; DNA synthesis involved in DNA repair; and DNA-templated DNA replication. Predicted to be located in membrane. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC6
Biological processes 16 terms
3'-UTR-mediated mRNA destabilization (GO:0061158)DNA biosynthetic process (GO:0071897)DNA integration (GO:0015074)DNA-directed DNA polymerase activity (GO:0003887)DNA-templated DNA replication (GO:0006261)RNA endonuclease activity (GO:0004521)RNA-DNA hybrid ribonuclease activity (GO:0004523)biological_process (GO:0008150)cellular_component (GO:0005575)chromosome (GO:0005694)cytoplasmic ribonucleoprotein granule (GO:0036464)mRNA binding (GO:0003729)membrane (GO:0016020)molecular_function (GO:0003674)nucleic acid binding (GO:0003676)nucleus (GO:0005634)
Expression (TPM)
NYNRIN — as a Regulated Gene

TFs regulating NYNRIN 0 TFs

Transcription factors with Perturb-seq knockdown data for NYNRIN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NYNRIN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to NYNRIN

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NYNRIN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:24,113,681–24,115,917 284.0 kb Distal (>10kb) Multiome 1166
chr14:24,135,549–24,136,884 262.9 kb Distal (>10kb) Multiome 778
chr14:24,140,526–24,142,331 257.3 kb Distal (>10kb) Multiome 1034
chr14:24,146,204–24,148,108 252.2 kb Distal (>10kb) Multiome 918
chr14:24,160,877–24,161,762 237.8 kb Distal (>10kb) Multiome 970
chr14:24,171,489–24,172,698 227.1 kb Distal (>10kb) Multiome 365
chr14:24,188,229–24,189,111 210.2 kb Distal (>10kb) Multiome 1074
chr14:24,195,072–24,196,365 203.4 kb Distal (>10kb) Multiome 1059
chr14:24,212,871–24,213,884 185.6 kb Distal (>10kb) Multiome 1036
chr14:24,215,523–24,216,241 183.0 kb Distal (>10kb) Multiome 955
chr14:24,231,706–24,233,147 166.4 kb Distal (>10kb) Multiome 1027
chr14:24,241,845–24,243,572 156.4 kb Distal (>10kb) Multiome 1077
chr14:24,270,770–24,271,924 127.6 kb Distal (>10kb) Multiome 1089
chr14:24,299,120–24,300,273 99.2 kb Distal (>10kb) Multiome 892
chr14:24,315,948–24,316,753 82.6 kb Distal (>10kb) Multiome 736
chr14:24,332,251–24,333,127 66.5 kb Distal (>10kb) Multiome 740
chr14:24,365,652–24,366,243 33.3 kb Distal (>10kb) Multiome 668
chr14:24,366,594–24,369,358 31.8 kb Distal (>10kb) Multiome 921
chr14:24,388,547–24,389,510 10.0 kb Distal (>10kb) Multiome 161
chr14:24,398,424–24,399,423 63 bp At TSS Multiome 354
chr14:24,429,597–24,431,070 31.1 kb Distal (>10kb) Multiome 903
chr14:24,431,554–24,432,205 32.9 kb Distal (>10kb) Multiome 604
chr14:24,441,935–24,443,373 43.6 kb Distal (>10kb) Multiome 1072
chr14:24,481,599–24,482,121 82.8 kb Distal (>10kb) Multiome 593

Genome Browser

Genomic view of the NYNRIN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:24,103,681 – 24,492,121
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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