This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Transcription factors with Perturb-seq knockdown data for NXPE3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NXPE3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NXPE3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:101,512,475–101,513,632 | 266.1 kb | Distal (>10kb) Multiome | 799 | |
| chr3:101,530,192–101,530,904 | 248.7 kb | Distal (>10kb) Multiome | 336 | |
| chr3:101,561,343–101,562,162 | 217.4 kb | Distal (>10kb) Multiome | 783 | |
| chr3:101,573,305–101,575,121 | 205.2 kb | Distal (>10kb) Multiome | 1039 | |
| chr3:101,641,500–101,642,206 | 137.5 kb | Distal (>10kb) Multiome | 397 | |
| chr3:101,724,220–101,725,851 | 54.4 kb | Distal (>10kb) Multiome | 749 | |
| chr3:101,778,676–101,779,992 | 59 bp | At TSS Multiome | 826 | |
| chr3:101,848,739–101,850,257 | 70.2 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the NXPE3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.