This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded protein is essential for dolichol synthesis and protein glycosylation. This gene is highly expressed in non-small cell lung carcinomas as well as estrogen receptor-alpha positive breast cancer cells where it promotes epithelial mesenchymal transition. This gene is associated with the poor prognosis of human hepatocellular carcinoma patients. Naturally occurring mutations in this gene cause a congenital disorder of glycosylation and are associated with epilepsy. A knockout of the orthologous gene in mice causes embryonic lethality before day 6.5. Pseudogenes of this gene have been defined on chromosomes 13 and X. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for NUS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:117,481,405–117,483,867 | 192.8 kb | Distal (>10kb) Multiome | 1094 | |
| chr6:117,552,410–117,553,719 | 122.5 kb | Distal (>10kb) Multiome | 173 | |
| chr6:117,601,873–117,603,119 | 72.9 kb | Distal (>10kb) Multiome | 1002 | |
| chr6:117,674,767–117,676,565 | 67 bp | At TSS Multiome | 884 | |
| chr6:117,906,483–117,908,933 | 232.8 kb | Distal (>10kb) Multiome | 630 | |
| chr6:117,919,757–117,920,784 | 244.7 kb | Distal (>10kb) Multiome | 345 | |
| chr6:117,951,635–117,952,270 | 276.5 kb | Distal (>10kb) Multiome | 165 |
Genomic view of the NUS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.