This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Transcription factors with Perturb-seq knockdown data for NUP85. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUP85 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUP85, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:74,923,198–74,923,804 | 282.1 kb | Distal (>10kb) Multiome | 543 | |
| chr17:74,972,019–74,973,116 | 232.9 kb | Distal (>10kb) Multiome | 607 | |
| chr17:74,982,006–74,982,936 | 223.3 kb | Distal (>10kb) Multiome | 952 | |
| chr17:74,987,081–74,988,770 | 218.1 kb | Distal (>10kb) Multiome | 702 | |
| chr17:75,012,158–75,013,285 | 192.9 kb | Distal (>10kb) Multiome | 1058 | |
| chr17:75,033,550–75,035,757 | 170.6 kb | Distal (>10kb) Multiome | 1228 | |
| chr17:75,046,451–75,047,855 | 158.6 kb | Distal (>10kb) Multiome | 961 | |
| chr17:75,087,344–75,088,429 | 117.9 kb | Distal (>10kb) Multiome | 717 | |
| chr17:75,089,013–75,089,866 | 116.3 kb | Distal (>10kb) Multiome | 406 | |
| chr17:75,104,838–75,106,094 | 99.9 kb | Distal (>10kb) Multiome | 454 | |
| chr17:75,109,401–75,110,734 | 95.8 kb | Distal (>10kb) Multiome | 762 | |
| chr17:75,113,757–75,114,535 | 91.5 kb | Distal (>10kb) Multiome | 585 | |
| chr17:75,130,577–75,132,090 | 74.0 kb | Distal (>10kb) Multiome | 990 | |
| chr17:75,153,354–75,155,273 | 51.1 kb | Distal (>10kb) Multiome | 993 | |
| chr17:75,182,199–75,183,441 | 22.7 kb | Distal (>10kb) Multiome | 908 | |
| chr17:75,205,060–75,205,995 | 194 bp | At TSS Multiome | 975 | |
| chr17:75,240,373–75,240,941 | 35.0 kb | Distal (>10kb) Multiome | 436 | |
| chr17:75,261,304–75,262,404 | 56.0 kb | Distal (>10kb) Multiome | 983 | |
| chr17:75,270,231–75,271,942 | 65.6 kb | Distal (>10kb) Multiome | 946 | |
| chr17:75,288,761–75,289,874 | 83.8 kb | Distal (>10kb) Multiome | 941 | |
| chr17:75,346,809–75,347,324 | 141.5 kb | Distal (>10kb) Multiome | 265 | |
| chr17:75,393,479–75,394,300 | 188.2 kb | Distal (>10kb) Multiome | 834 | |
| chr17:75,404,856–75,406,161 | 200.1 kb | Distal (>10kb) Multiome | 917 | |
| chr17:75,456,149–75,457,264 | 250.9 kb | Distal (>10kb) Multiome | 865 | |
| chr17:75,481,081–75,481,680 | 275.7 kb | Distal (>10kb) Multiome | 64 |
Genomic view of the NUP85 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.