This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NUP58. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUP58 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUP58, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:25,047,042–25,047,668 | 254.4 kb | Distal (>10kb) Multiome | 177 | |
| chr13:25,170,532–25,171,326 | 130.7 kb | Distal (>10kb) Multiome | 133 | |
| chr13:25,286,940–25,287,682 | 14.2 kb | Distal (>10kb) Multiome | 766 | |
| chr13:25,300,888–25,302,118 | 45 bp | At TSS Multiome | 741 | |
| chr13:25,371,861–25,372,751 | 70.6 kb | Distal (>10kb) Multiome | 208 | |
| chr13:25,468,253–25,469,387 | 167.2 kb | Distal (>10kb) Multiome | 220 |
Genomic view of the NUP58 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.