Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for NUP43. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUP43 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUP43, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:149,545,230–149,546,831 | 200.4 kb | Distal (>10kb) Multiome | 1020 | |
| chr6:149,565,581–149,567,238 | 180.3 kb | Distal (>10kb) Multiome | 1021 | |
| chr6:149,648,112–149,649,264 | 97.9 kb | Distal (>10kb) Multiome | 1051 | |
| chr6:149,708,994–149,710,258 | 36.9 kb | Distal (>10kb) Multiome | 141 | |
| chr6:149,717,353–149,718,457 | 28.5 kb | Distal (>10kb) Multiome | 1074 | |
| chr6:149,746,178–149,746,876 | 17 bp | At TSS Multiome | 812 | |
| chr6:149,749,354–149,750,638 | 3.2 kb | Proximal (<10kb) Multiome | 967 | |
| chr6:149,845,261–149,846,647 | 99.2 kb | Distal (>10kb) Multiome | 234 | |
| chr6:149,863,201–149,865,192 | 116.8 kb | Distal (>10kb) Multiome | 906 | |
| chr6:149,922,648–149,923,559 | 176.6 kb | Distal (>10kb) Multiome | 419 | |
| chr6:149,925,530–149,926,657 | 179.7 kb | Distal (>10kb) Multiome | 390 | |
| chr6:149,941,434–149,942,626 | 195.4 kb | Distal (>10kb) Multiome | 476 | |
| chr6:149,963,109–149,964,540 | 217.2 kb | Distal (>10kb) Multiome | 691 | |
| chr6:150,004,529–150,006,027 | 258.7 kb | Distal (>10kb) Multiome | 798 |
Genomic view of the NUP43 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.