NUP42

nucleoporin 42 | CG1, H_RG271G13.9, NLP_1, hCG1, NUPL2

Enables nuclear export signal receptor activity. Involved in protein export from nucleus. Located in cytosol; nuclear membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1

Biological processes 16 terms

RNA binding (GO:0003723)cytosol (GO:0005829)metal ion binding (GO:0046872)nuclear envelope (GO:0005635)nuclear envelope (GO:0005635)nuclear envelope (GO:0005635)nuclear export signal receptor activity (GO:0005049)nuclear export signal receptor activity (GO:0005049)nuclear membrane (GO:0031965)nuclear membrane (GO:0031965)nuclear pore (GO:0005643)nucleocytoplasmic transport (GO:0006913)nucleoplasm (GO:0005654)nucleus (GO:0005634)protein binding (GO:0005515)protein export from nucleus (GO:0006611)

Expression (TPM)

TFs regulating NUP42 0 TFs

Transcription factors with Perturb-seq knockdown data for NUP42. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUP42 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NUP42

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUP42, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:22,937,587–22,938,683	243.8 kb	Distal (>10kb) Multiome	139
chr7:23,013,184–23,014,464	167.8 kb	Distal (>10kb) Multiome	751
chr7:23,105,409–23,106,715	76.2 kb	Distal (>10kb) Multiome	833
chr7:23,116,020–23,116,472	65.9 kb	Distal (>10kb) Multiome	105
chr7:23,181,578–23,182,460	50 bp	At TSS Multiome	935
chr7:23,205,915–23,206,590	24.2 kb	Distal (>10kb) Multiome	154
chr7:23,247,362–23,248,065	65.7 kb	Distal (>10kb) Multiome	202
chr7:23,299,105–23,299,994	117.3 kb	Distal (>10kb) Multiome	852
chr7:23,465,333–23,465,840	283.5 kb	Distal (>10kb) Multiome	410
chr7:23,470,190–23,471,917	289.3 kb	Distal (>10kb) Multiome	922
chr7:23,473,588–23,475,134	292.4 kb	Distal (>10kb) Multiome	996

Genome Browser

Genomic view of the NUP42 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.