The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for NUP214. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUP214 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUP214, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:130,834,623–130,835,640 | 290.4 kb | Distal (>10kb) Multiome | 715 | |
| chr9:130,940,926–130,941,385 | 184.4 kb | Distal (>10kb) Multiome | 359 | |
| chr9:130,998,218–130,998,819 | 127.1 kb | Distal (>10kb) Multiome | 380 | |
| chr9:131,008,758–131,009,603 | 116.4 kb | Distal (>10kb) Multiome | 393 | |
| chr9:131,096,120–131,097,337 | 29.1 kb | Distal (>10kb) Multiome | 533 | |
| chr9:131,125,092–131,126,077 | 80 bp | At TSS Multiome | 873 | |
| chr9:131,177,994–131,178,580 | 52.8 kb | Distal (>10kb) Multiome | 304 | |
| chr9:131,276,571–131,278,332 | 152.5 kb | Distal (>10kb) Multiome | 558 | |
| chr9:131,282,624–131,283,561 | 157.4 kb | Distal (>10kb) Multiome | 217 | |
| chr9:131,330,816–131,331,776 | 205.8 kb | Distal (>10kb) Multiome | 463 | |
| chr9:131,349,882–131,350,535 | 224.6 kb | Distal (>10kb) Multiome | 525 | |
| chr9:131,373,092–131,374,082 | 248.0 kb | Distal (>10kb) Multiome | 962 | |
| chr9:131,393,060–131,394,879 | 268.3 kb | Distal (>10kb) Multiome | 722 | |
| chr9:131,407,727–131,408,216 | 282.4 kb | Distal (>10kb) Multiome | 172 |
Genomic view of the NUP214 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.