This gene encodes a nucleoporin, which is a subunit of the nuclear pore complex that functions in active transport of proteins, RNAs and ribonucleoprotein particles between the nucleus and cytoplasm. Mutations in this gene are associated with steroid-resistant nephrotic syndrome. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for NUP205. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUP205 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUP205, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:135,335,404–135,336,080 | 222.1 kb | Distal (>10kb) Multiome | 567 | |
| chr7:135,509,171–135,510,811 | 47.7 kb | Distal (>10kb) Multiome | 903 | |
| chr7:135,557,472–135,558,749 | 10 bp | At TSS Multiome | 957 | |
| chr7:135,561,679–135,562,109 | 3.7 kb | Proximal (<10kb) | 73 | |
| chr7:135,562,644–135,563,104 | 5.0 kb | Proximal (<10kb) Multiome | 115 | |
| chr7:135,661,395–135,663,087 | 104.5 kb | Distal (>10kb) Multiome | 1079 | |
| chr7:135,727,964–135,728,827 | 170.4 kb | Distal (>10kb) Multiome | 212 |
Genomic view of the NUP205 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.