Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for NUP155. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUP155 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUP155, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:37,086,434–37,087,024 | 284.4 kb | Distal (>10kb) Multiome | 249 | |
| chr5:37,090,010–37,091,198 | 280.6 kb | Distal (>10kb) Multiome | 257 | |
| chr5:37,248,873–37,250,119 | 121.7 kb | Distal (>10kb) Multiome | 766 | |
| chr5:37,370,778–37,371,902 | 170 bp | At TSS Multiome | 899 | |
| chr5:37,379,009–37,379,643 | 8.2 kb | Proximal (<10kb) Multiome | 490 |
Genomic view of the NUP155 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.