This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for NUDT5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUDT5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUDT5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:11,913,209–11,913,675 | 282.4 kb | Distal (>10kb) Multiome | 34 | |
| chr10:12,041,862–12,043,685 | 152.8 kb | Distal (>10kb) Multiome | 849 | |
| chr10:12,063,340–12,063,818 | 132.3 kb | Distal (>10kb) Multiome | 219 | |
| chr10:12,068,387–12,069,409 | 127.0 kb | Distal (>10kb) Multiome | 831 | |
| chr10:12,129,046–12,130,594 | 66.3 kb | Distal (>10kb) Multiome | 734 | |
| chr10:12,195,567–12,196,550 | 187 bp | At TSS Multiome | 929 | |
| chr10:12,264,254–12,264,720 | 68.5 kb | Distal (>10kb) Multiome | 542 | |
| chr10:12,348,533–12,350,063 | 153.5 kb | Distal (>10kb) Multiome | 473 | |
| chr10:12,444,721–12,445,267 | 249.0 kb | Distal (>10kb) Multiome | 44 |
Genomic view of the NUDT5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.