This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for NUDT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUDT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUDT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:34,048,315–34,049,845 | 280.4 kb | Distal (>10kb) Multiome | 1045 | |
| chr9:34,049,943–34,050,924 | 279.0 kb | Distal (>10kb) Multiome | 283 | |
| chr9:34,126,146–34,127,302 | 202.9 kb | Distal (>10kb) Multiome | 826 | |
| chr9:34,178,460–34,179,845 | 150.5 kb | Distal (>10kb) Multiome | 814 | |
| chr9:34,328,711–34,329,961 | 157 bp | At TSS Multiome | 768 | |
| chr9:34,330,062–34,330,410 | 494 bp | At TSS | 143 | |
| chr9:34,334,286–34,334,550 | 4.7 kb | Proximal (<10kb) | 159 | |
| chr9:34,363,597–34,364,212 | 34.4 kb | Distal (>10kb) Multiome | 104 | |
| chr9:34,374,953–34,375,681 | 45.7 kb | Distal (>10kb) Multiome | 432 | |
| chr9:34,376,008–34,377,655 | 47.5 kb | Distal (>10kb) Multiome | 779 | |
| chr9:34,379,248–34,381,674 | 51.3 kb | Distal (>10kb) Multiome | 763 | |
| chr9:34,456,881–34,459,235 | 129.1 kb | Distal (>10kb) Multiome | 704 | |
| chr9:34,522,211–34,523,972 | 193.6 kb | Distal (>10kb) Multiome | 473 | |
| chr9:34,577,374–34,578,752 | 248.5 kb | Distal (>10kb) Multiome | 204 | |
| chr9:34,589,298–34,591,068 | 260.3 kb | Distal (>10kb) Multiome | 258 | |
| chr9:34,591,283–34,592,013 | 262.3 kb | Distal (>10kb) Multiome | 368 | |
| chr9:34,611,663–34,612,738 | 282.6 kb | Distal (>10kb) Multiome | 680 | |
| chr9:34,612,834–34,613,263 | 283.5 kb | Distal (>10kb) Multiome | 343 | |
| chr9:34,620,108–34,620,704 | 290.9 kb | Distal (>10kb) Multiome | 467 | |
| chr9:34,628,770–34,629,308 | 299.5 kb | Distal (>10kb) Multiome | 216 |
Genomic view of the NUDT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.