Enables snoRNA binding activity. Involved in negative regulation of double-strand break repair via nonhomologous end joining. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NUDT16L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUDT16L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUDT16L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:4,402,485–4,403,104 | 290.9 kb | Distal (>10kb) Multiome | 450 | |
| chr16:4,415,818–4,417,201 | 277.0 kb | Distal (>10kb) Multiome | 681 | |
| chr16:4,425,392–4,426,322 | 268.0 kb | Distal (>10kb) Multiome | 881 | |
| chr16:4,474,111–4,474,929 | 219.1 kb | Distal (>10kb) Multiome | 626 | |
| chr16:4,476,027–4,477,237 | 217.3 kb | Distal (>10kb) Multiome | 841 | |
| chr16:4,537,639–4,538,998 | 155.1 kb | Distal (>10kb) Multiome | 1087 | |
| chr16:4,585,331–4,585,992 | 108.1 kb | Distal (>10kb) Multiome | 223 | |
| chr16:4,613,912–4,617,164 | 78.8 kb | Distal (>10kb) Multiome | 1079 | |
| chr16:4,624,301–4,625,703 | 69.0 kb | Distal (>10kb) Multiome | 866 | |
| chr16:4,693,016–4,694,663 | 118 bp | At TSS Multiome | 730 | |
| chr16:4,733,836–4,735,221 | 40.7 kb | Distal (>10kb) Multiome | 858 | |
| chr16:4,766,728–4,767,628 | 73.5 kb | Distal (>10kb) Multiome | 795 | |
| chr16:4,768,438–4,769,162 | 75.1 kb | Distal (>10kb) Multiome | 677 | |
| chr16:4,801,836–4,803,175 | 108.6 kb | Distal (>10kb) Multiome | 743 | |
| chr16:4,846,559–4,848,209 | 153.7 kb | Distal (>10kb) Multiome | 803 | |
| chr16:4,936,143–4,937,673 | 243.6 kb | Distal (>10kb) Multiome | 655 | |
| chr16:4,943,173–4,943,813 | 249.7 kb | Distal (>10kb) Multiome | 609 | |
| chr16:4,957,489–4,958,782 | 264.4 kb | Distal (>10kb) Multiome HiCAR | 802 |
Genomic view of the NUDT16L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.