This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for NUDT15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUDT15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUDT15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:46,796,424–46,797,697 | 1240.6 kb | Distal (>10kb) Multiome HiCAR | 930 | |
| chr13:48,000,679–48,002,503 | 36.4 kb | Distal (>10kb) Multiome | 801 | |
| chr13:48,037,295–48,039,275 | 114 bp | At TSS Multiome | 1096 | |
| chr13:48,094,468–48,095,500 | 57.4 kb | Distal (>10kb) Multiome | 866 | |
| chr13:48,232,588–48,234,160 | 195.4 kb | Distal (>10kb) Multiome | 750 | |
| chr13:48,303,216–48,304,354 | 266.0 kb | Distal (>10kb) Multiome | 827 |
Genomic view of the NUDT15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.