The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NUDCD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUDCD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUDCD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:44,200,748–44,201,465 | 289.6 kb | Distal (>10kb) Multiome | 738 | |
| chr7:44,218,223–44,218,706 | 272.2 kb | Distal (>10kb) Multiome | 215 | |
| chr7:44,275,748–44,276,529 | 214.4 kb | Distal (>10kb) Multiome | 146 | |
| chr7:44,309,084–44,310,124 | 180.8 kb | Distal (>10kb) Multiome | 263 | |
| chr7:44,325,052–44,325,687 | 165.2 kb | Distal (>10kb) Multiome | 118 | |
| chr7:44,490,144–44,491,030 | 73 bp | At TSS Multiome | 996 | |
| chr7:44,573,627–44,574,398 | 83.4 kb | Distal (>10kb) Multiome | 885 | |
| chr7:44,581,475–44,583,147 | 91.8 kb | Distal (>10kb) Multiome | 864 | |
| chr7:44,606,125–44,607,487 | 116.2 kb | Distal (>10kb) Multiome | 1043 | |
| chr7:44,748,085–44,749,703 | 258.0 kb | Distal (>10kb) Multiome | 665 |
Genomic view of the NUDCD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.