This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Transcription factors with Perturb-seq knockdown data for NTRK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NTRK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NTRK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:88,072,799–88,073,663 | 183.4 kb | Distal (>10kb) Multiome | 140 | |
| chr15:88,246,462–88,247,390 | 9.8 kb | Proximal (<10kb) Multiome | 349 | |
| chr15:88,255,061–88,256,172 | 618 bp | At TSS | 168 | |
| chr15:88,256,294–88,256,454 | 336 bp | At TSS | 84 | |
| chr15:88,256,583–88,257,904 | 54 bp | At TSS Multiome | 199 | |
| chr15:88,258,031–88,258,757 | 1.6 kb | Proximal (<10kb) Multiome | 208 | |
| chr15:88,467,068–88,468,013 | 210.7 kb | Distal (>10kb) Multiome | 857 | |
| chr15:88,545,733–88,547,888 | 289.8 kb | Distal (>10kb) Multiome | 818 |
Genomic view of the NTRK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.