This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for NT5C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NT5C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NT5C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:74,842,511–74,843,541 | 288.8 kb | Distal (>10kb) Multiome | 412 | |
| chr17:74,852,259–74,853,211 | 279.1 kb | Distal (>10kb) Multiome | 435 | |
| chr17:74,872,506–74,873,926 | 258.6 kb | Distal (>10kb) Multiome | 1008 | |
| chr17:74,893,600–74,894,183 | 238.0 kb | Distal (>10kb) Multiome | 189 | |
| chr17:74,923,198–74,923,804 | 208.2 kb | Distal (>10kb) Multiome | 543 | |
| chr17:74,972,019–74,973,116 | 159.0 kb | Distal (>10kb) Multiome | 607 | |
| chr17:74,982,006–74,982,936 | 149.4 kb | Distal (>10kb) Multiome | 952 | |
| chr17:74,987,081–74,988,770 | 144.1 kb | Distal (>10kb) Multiome | 702 | |
| chr17:75,012,158–75,013,285 | 119.0 kb | Distal (>10kb) Multiome | 1058 | |
| chr17:75,033,550–75,035,757 | 96.6 kb | Distal (>10kb) Multiome | 1228 | |
| chr17:75,046,451–75,047,855 | 84.7 kb | Distal (>10kb) Multiome | 961 | |
| chr17:75,087,344–75,088,429 | 44.0 kb | Distal (>10kb) Multiome | 717 | |
| chr17:75,089,013–75,089,866 | 42.4 kb | Distal (>10kb) Multiome | 406 | |
| chr17:75,104,838–75,106,094 | 26.0 kb | Distal (>10kb) Multiome | 454 | |
| chr17:75,109,401–75,110,734 | 21.8 kb | Distal (>10kb) Multiome | 762 | |
| chr17:75,113,757–75,114,535 | 17.6 kb | Distal (>10kb) Multiome | 585 | |
| chr17:75,130,577–75,132,090 | 58 bp | At TSS Multiome | 990 | |
| chr17:75,153,354–75,155,273 | 22.8 kb | Distal (>10kb) Multiome | 993 | |
| chr17:75,182,199–75,183,441 | 51.3 kb | Distal (>10kb) Multiome | 908 | |
| chr17:75,205,060–75,205,995 | 73.7 kb | Distal (>10kb) Multiome | 975 | |
| chr17:75,240,373–75,240,941 | 108.9 kb | Distal (>10kb) Multiome | 436 | |
| chr17:75,261,304–75,262,404 | 130.0 kb | Distal (>10kb) Multiome | 983 | |
| chr17:75,270,231–75,271,942 | 139.5 kb | Distal (>10kb) Multiome | 946 | |
| chr17:75,288,761–75,289,874 | 157.8 kb | Distal (>10kb) Multiome | 941 | |
| chr17:75,346,809–75,347,324 | 215.4 kb | Distal (>10kb) Multiome | 265 | |
| chr17:75,393,479–75,394,300 | 262.2 kb | Distal (>10kb) Multiome | 834 | |
| chr17:75,404,856–75,406,161 | 274.0 kb | Distal (>10kb) Multiome | 917 |
Genomic view of the NT5C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.