Enables mRNA binding activity. Involved in developmental process and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NSRP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NSRP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NSRP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:29,929,376–29,930,689 | 186.7 kb | Distal (>10kb) Multiome | 768 | |
| chr17:30,104,595–30,105,065 | 12.0 kb | Distal (>10kb) Multiome | 585 | |
| chr17:30,116,470–30,117,077 | 20 bp | At TSS Multiome | 800 | |
| chr17:30,291,554–30,292,527 | 175.3 kb | Distal (>10kb) Multiome | 724 | |
| chr17:30,340,166–30,340,693 | 223.7 kb | Distal (>10kb) Multiome | 394 | |
| chr17:30,378,665–30,379,625 | 262.1 kb | Distal (>10kb) Multiome | 693 |
Genomic view of the NSRP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.