This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for NRN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NRN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NRN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:5,994,270–5,995,166 | 8.9 kb | Proximal (<10kb) | 57 | |
| chr6:5,995,805–5,997,966 | 6.1 kb | Proximal (<10kb) | 498 | |
| chr6:5,998,939–6,000,243 | 3.8 kb | Proximal (<10kb) | 192 | |
| chr6:6,001,989–6,002,938 | 1.1 kb | Proximal (<10kb) | 114 | |
| chr6:6,003,214–6,004,376 | at TSS | At TSS | 320 | |
| chr6:6,004,496–6,004,820 | 452 bp | At TSS | 131 | |
| chr6:6,007,231–6,008,138 | 3.2 kb | Proximal (<10kb) | 406 | |
| chr6:6,008,365–6,009,394 | 4.3 kb | Proximal (<10kb) | 472 |
Genomic view of the NRN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.