The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for NRM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NRM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NRM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:30,466,230–30,466,713 | 224.4 kb | Distal (>10kb) Multiome | 369 | |
| chr6:30,489,117–30,490,512 | 200.7 kb | Distal (>10kb) Multiome | 750 | |
| chr6:30,516,006–30,516,707 | 174.6 kb | Distal (>10kb) Multiome | 739 | |
| chr6:30,555,407–30,557,765 | 134.4 kb | Distal (>10kb) Multiome | 1161 | |
| chr6:30,570,822–30,571,949 | 119.6 kb | Distal (>10kb) Multiome | 1000 | |
| chr6:30,614,393–30,615,939 | 75.8 kb | Distal (>10kb) Multiome | 837 | |
| chr6:30,616,770–30,618,155 | 73.5 kb | Distal (>10kb) Multiome | 1072 | |
| chr6:30,626,560–30,627,206 | 64.1 kb | Distal (>10kb) Multiome | 802 | |
| chr6:30,646,505–30,648,035 | 43.7 kb | Distal (>10kb) Multiome | 961 | |
| chr6:30,672,571–30,673,266 | 18.0 kb | Distal (>10kb) Multiome | 812 | |
| chr6:30,679,032–30,679,479 | 11.8 kb | Distal (>10kb) Multiome | 603 | |
| chr6:30,686,268–30,688,032 | 3.8 kb | Proximal (<10kb) Multiome | 801 | |
| chr6:30,690,445–30,691,240 | 41 bp | At TSS Multiome | 644 | |
| chr6:30,691,610–30,691,795 | 887 bp | At TSS | 74 | |
| chr6:30,716,986–30,717,874 | 26.5 kb | Distal (>10kb) Multiome | 1059 | |
| chr6:30,719,428–30,720,577 | 29.2 kb | Distal (>10kb) Multiome | 724 | |
| chr6:30,721,307–30,722,103 | 30.5 kb | Distal (>10kb) Multiome | 872 | |
| chr6:30,725,731–30,726,564 | 35.2 kb | Distal (>10kb) Multiome | 478 | |
| chr6:30,740,996–30,745,094 | 51.7 kb | Distal (>10kb) Multiome | 1233 | |
| chr6:30,763,647–30,765,193 | 73.4 kb | Distal (>10kb) Multiome | 850 | |
| chr6:30,880,638–30,881,295 | 190.0 kb | Distal (>10kb) Multiome | 124 | |
| chr6:30,882,560–30,883,422 | 191.9 kb | Distal (>10kb) Multiome | 308 | |
| chr6:30,883,625–30,885,122 | 193.4 kb | Distal (>10kb) Multiome | 538 | |
| chr6:30,907,770–30,908,494 | 217.1 kb | Distal (>10kb) Multiome | 1005 | |
| chr6:30,913,674–30,914,800 | 223.2 kb | Distal (>10kb) Multiome | 944 | |
| chr6:30,942,475–30,943,087 | 251.8 kb | Distal (>10kb) Multiome | 300 | |
| chr6:30,955,192–30,955,975 | 264.7 kb | Distal (>10kb) Multiome | 524 |
Genomic view of the NRM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.