NRBP1

nuclear receptor binding protein 1 | BCON3, MADM, MUDPNP, NRBP

Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endomembrane system. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1

Biological processes 24 terms

ATP binding (GO:0005524)DNA damage response (GO:0006974)cell cortex (GO:0005938)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)endomembrane system (GO:0012505)endomembrane system (GO:0012505)endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888)epithelial cell differentiation (GO:0030855)epithelial cell proliferation (GO:0050673)identical protein binding (GO:0042802)in utero embryonic development (GO:0001701)intracellular signal transduction (GO:0035556)lamellipodium (GO:0030027)nucleoplasm (GO:0005654)perinuclear region of cytoplasm (GO:0048471)positive regulation of canonical Wnt signaling pathway (GO:0090263)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)protein kinase activity (GO:0004672)protein serine/threonine kinase activity (GO:0004674)regulation of monoatomic cation transmembrane transport (GO:1904062)

Expression (TPM)

TFs regulating NRBP1 0 TFs

Transcription factors with Perturb-seq knockdown data for NRBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NRBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NRBP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NRBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:27,133,917–27,135,216	293.9 kb	Distal (>10kb) Multiome	815
chr2:27,211,255–27,212,840	216.5 kb	Distal (>10kb) Multiome	978
chr2:27,217,045–27,218,005	211.2 kb	Distal (>10kb) Multiome	771
chr2:27,250,040–27,250,883	178.2 kb	Distal (>10kb) Multiome	559
chr2:27,262,260–27,263,337	165.7 kb	Distal (>10kb) Multiome	376
chr2:27,264,406–27,265,326	163.5 kb	Distal (>10kb) Multiome	696
chr2:27,306,488–27,307,261	122.0 kb	Distal (>10kb) Multiome	115
chr2:27,322,773–27,323,423	105.5 kb	Distal (>10kb) Multiome	906
chr2:27,356,094–27,357,596	71.7 kb	Distal (>10kb) Multiome	1084
chr2:27,369,685–27,371,261	58.2 kb	Distal (>10kb) Multiome	1096
chr2:27,380,026–27,381,202	47.8 kb	Distal (>10kb) Multiome	821
chr2:27,408,972–27,410,056	19.0 kb	Distal (>10kb) Multiome	989
chr2:27,428,202–27,429,633	31 bp	At TSS Multiome	1013
chr2:27,441,811–27,442,884	13.8 kb	Distal (>10kb) Multiome	380
chr2:27,489,334–27,490,205	61.2 kb	Distal (>10kb) Multiome	731
chr2:27,494,797–27,495,577	66.6 kb	Distal (>10kb) Multiome	380
chr2:27,517,085–27,517,958	88.9 kb	Distal (>10kb) Multiome	130
chr2:27,582,572–27,583,317	154.3 kb	Distal (>10kb) Multiome	843
chr2:27,628,534–27,629,380	200.4 kb	Distal (>10kb) Multiome	828
chr2:27,663,338–27,664,216	235.1 kb	Distal (>10kb) Multiome	1035
chr2:27,681,105–27,682,049	253.0 kb	Distal (>10kb) Multiome	85
chr2:27,715,293–27,715,981	287.3 kb	Distal (>10kb) Multiome	346

Genome Browser

Genomic view of the NRBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.