Involved in autophagy. Located in cytoplasm and phosphatidylinositol 3-kinase complex, class III. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NRBF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NRBF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NRBF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:62,924,256–62,924,920 | 208.6 kb | Distal (>10kb) Multiome | 231 | |
| chr10:63,132,822–63,134,026 | 38 bp | At TSS Multiome | 964 | |
| chr10:63,268,784–63,269,452 | 135.9 kb | Distal (>10kb) Multiome | 834 | |
| chr10:63,347,833–63,349,212 | 215.3 kb | Distal (>10kb) Multiome | 254 | |
| chr10:63,629,052–63,631,108 | 496.5 kb | Distal (>10kb) Multiome HiCAR | 968 | |
| chr10:63,713,131–63,714,105 | 580.3 kb | Distal (>10kb) Multiome HiCAR | 440 |
Genomic view of the NRBF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.