Involved in Notch signaling pathway. Acts upstream of or within negative regulation of Notch signaling pathway and positive regulation of canonical Wnt signaling pathway. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NRARP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NRARP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NRARP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:137,027,536–137,029,054 | 274.0 kb | Distal (>10kb) Multiome | 539 | |
| chr9:137,045,334–137,046,838 | 255.8 kb | Distal (>10kb) Multiome | 829 | |
| chr9:137,053,352–137,054,892 | 248.1 kb | Distal (>10kb) Multiome | 544 | |
| chr9:137,067,810–137,068,494 | 234.2 kb | Distal (>10kb) Multiome | 492 | |
| chr9:137,069,879–137,071,138 | 231.6 kb | Distal (>10kb) Multiome | 703 | |
| chr9:137,076,758–137,078,723 | 224.9 kb | Distal (>10kb) Multiome | 530 | |
| chr9:137,085,844–137,087,716 | 215.4 kb | Distal (>10kb) Multiome | 890 | |
| chr9:137,129,244–137,130,499 | 172.4 kb | Distal (>10kb) Multiome | 823 | |
| chr9:137,167,984–137,170,155 | 134.1 kb | Distal (>10kb) Multiome | 560 | |
| chr9:137,188,099–137,189,538 | 113.5 kb | Distal (>10kb) Multiome | 954 | |
| chr9:137,200,175–137,201,689 | 101.4 kb | Distal (>10kb) Multiome | 856 | |
| chr9:137,205,371–137,205,975 | 96.6 kb | Distal (>10kb) Multiome | 758 | |
| chr9:137,221,373–137,224,294 | 78.7 kb | Distal (>10kb) Multiome | 843 | |
| chr9:137,236,161–137,237,143 | 65.6 kb | Distal (>10kb) Multiome | 748 | |
| chr9:137,239,991–137,242,933 | 61.2 kb | Distal (>10kb) Multiome | 1117 | |
| chr9:137,253,801–137,256,036 | 47.0 kb | Distal (>10kb) Multiome | 843 | |
| chr9:137,280,593–137,281,861 | 21.0 kb | Distal (>10kb) Multiome | 223 | |
| chr9:137,294,373–137,294,560 | 7.7 kb | Proximal (<10kb) | 367 | |
| chr9:137,294,859–137,296,916 | 6.6 kb | Proximal (<10kb) Multiome | 501 | |
| chr9:137,300,591–137,303,141 | 186 bp | At TSS Multiome | 790 | |
| chr9:137,303,311–137,303,605 | 1.0 kb | Proximal (<10kb) | 148 | |
| chr9:137,316,104–137,316,916 | 14.2 kb | Distal (>10kb) Multiome HiCAR | 395 | |
| chr9:137,406,843–137,407,556 | 104.9 kb | Distal (>10kb) Multiome HiCAR | 427 | |
| chr9:137,422,664–137,424,024 | 121.0 kb | Distal (>10kb) Multiome HiCAR | 896 | |
| chr9:137,441,270–137,441,970 | 139.3 kb | Distal (>10kb) Multiome HiCAR | 568 | |
| chr9:137,453,153–137,455,543 | 151.8 kb | Distal (>10kb) Multiome | 727 | |
| chr9:137,458,468–137,459,887 | 157.1 kb | Distal (>10kb) Multiome | 613 | |
| chr9:137,461,555–137,462,160 | 159.6 kb | Distal (>10kb) Multiome | 284 | |
| chr9:137,551,136–137,552,512 | 249.5 kb | Distal (>10kb) Multiome | 756 | |
| chr9:137,578,523–137,579,553 | 276.7 kb | Distal (>10kb) Multiome | 910 | |
| chr9:137,589,526–137,591,323 | 288.3 kb | Distal (>10kb) Multiome | 623 |
Genomic view of the NRARP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.