This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NPTXR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NPTXR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NPTXR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:38,569,664–38,571,256 | 273.7 kb | Distal (>10kb) Multiome | 559 | |
| chr22:38,655,982–38,657,104 | 187.6 kb | Distal (>10kb) Multiome | 698 | |
| chr22:38,681,730–38,682,262 | 162.1 kb | Distal (>10kb) Multiome | 947 | |
| chr22:38,700,377–38,701,744 | 143.0 kb | Distal (>10kb) Multiome | 916 | |
| chr22:38,705,151–38,706,595 | 138.3 kb | Distal (>10kb) Multiome | 821 | |
| chr22:38,755,428–38,756,383 | 88.0 kb | Distal (>10kb) Multiome | 770 | |
| chr22:38,793,674–38,794,378 | 49.9 kb | Distal (>10kb) Multiome | 484 | |
| chr22:38,843,207–38,844,443 | 92 bp | At TSS Multiome | 585 | |
| chr22:38,866,394–38,866,832 | 22.6 kb | Distal (>10kb) Multiome | 76 | |
| chr22:38,871,208–38,873,237 | 28.3 kb | Distal (>10kb) Multiome | 758 |
Genomic view of the NPTXR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.