The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for NPM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NPM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NPM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:171,308,499–171,310,470 | 78.7 kb | Distal (>10kb) Multiome | 460 | |
| chr5:171,310,975–171,311,886 | 76.4 kb | Distal (>10kb) Multiome | 164 | |
| chr5:171,316,120–171,317,100 | 71.2 kb | Distal (>10kb) Multiome | 101 | |
| chr5:171,386,891–171,389,037 | 171 bp | At TSS Multiome | 1051 | |
| chr5:171,418,369–171,420,785 | 31.1 kb | Distal (>10kb) Multiome | 666 | |
| chr5:171,450,479–171,451,497 | 63.2 kb | Distal (>10kb) Multiome | 311 | |
| chr5:171,520,077–171,521,278 | 132.8 kb | Distal (>10kb) Multiome | 240 | |
| chr5:171,623,490–171,624,348 | 235.9 kb | Distal (>10kb) Multiome | 279 | |
| chr5:171,630,087–171,630,561 | 242.4 kb | Distal (>10kb) Multiome | 249 | |
| chr5:171,667,723–171,668,178 | 280.1 kb | Distal (>10kb) Multiome | 166 |
Genomic view of the NPM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.