Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NPIPB5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NPIPB5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NPIPB5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:22,205,924–22,206,847 | 299.6 kb | Distal (>10kb) Multiome | 1038 | |
| chr16:22,296,790–22,298,718 | 207.2 kb | Distal (>10kb) Multiome | 1288 | |
| chr16:22,373,797–22,375,383 | 131.1 kb | Distal (>10kb) Multiome | 951 | |
| chr16:22,436,881–22,437,622 | 68.7 kb | Distal (>10kb) Multiome | 642 | |
| chr16:22,634,974–22,635,717 | 129.5 kb | Distal (>10kb) Multiome | 127 | |
| chr16:22,727,898–22,728,946 | 222.5 kb | Distal (>10kb) Multiome | 321 |
Genomic view of the NPIPB5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.