Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NPIPB15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NPIPB15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NPIPB15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:74,100,517–74,101,228 | 276.9 kb | Distal (>10kb) Multiome | 122 | |
| chr16:74,296,459–74,297,197 | 81.1 kb | Distal (>10kb) Multiome | 1047 | |
| chr16:74,367,658–74,368,475 | 9.7 kb | Proximal (<10kb) Multiome | 473 | |
| chr16:74,495,325–74,495,916 | 117.7 kb | Distal (>10kb) Multiome | 90 | |
| chr16:74,606,340–74,607,641 | 229.2 kb | Distal (>10kb) Multiome | 1020 | |
| chr16:74,666,411–74,667,145 | 289.1 kb | Distal (>10kb) Multiome | 858 |
Genomic view of the NPIPB15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.