Enables box C/D methylation guide snoRNP complex binding activity. Involved in box C/D snoRNP assembly. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NOPCHAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOPCHAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOPCHAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:104,215,473–104,216,381 | 770.4 kb | Distal (>10kb) Multiome HiCAR | 514 | |
| chr12:104,722,661–104,723,450 | 263.3 kb | Distal (>10kb) Multiome | 215 | |
| chr12:104,957,697–104,958,992 | 28.0 kb | Distal (>10kb) Multiome | 811 | |
| chr12:104,986,118–104,986,938 | 10 bp | At TSS Multiome | 665 | |
| chr12:105,083,642–105,085,161 | 98.2 kb | Distal (>10kb) Multiome | 490 | |
| chr12:105,107,164–105,108,312 | 121.4 kb | Distal (>10kb) Multiome | 1033 | |
| chr12:105,235,605–105,236,419 | 249.7 kb | Distal (>10kb) Multiome | 802 |
Genomic view of the NOPCHAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.