NOP9
NOP9 nucleolar protein | C14orf21

Enables RNA binding activity. Predicted to be involved in ribosome biogenesis. Predicted to be part of 90S preribosome and preribosome, small subunit precursor. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC1
Biological processes 12 terms
90S preribosome (GO:0030686)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA binding (GO:0003723)biological_process (GO:0008150)cellular_component (GO:0005575)endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000480)endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000447)endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000472)nucleolus (GO:0005730)preribosome, small subunit precursor (GO:0030688)ribosomal small subunit export from nucleus (GO:0000056)
Expression (TPM)
NOP9 — as a Regulated Gene

TFs regulating NOP9 0 TFs

Transcription factors with Perturb-seq knockdown data for NOP9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOP9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to NOP9

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOP9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:24,036,218–24,036,993 263.3 kb Distal (>10kb) Multiome 627
chr14:24,051,239–24,052,875 247.4 kb Distal (>10kb) Multiome 821
chr14:24,080,914–24,082,038 218.4 kb Distal (>10kb) Multiome 706
chr14:24,093,491–24,095,115 205.7 kb Distal (>10kb) Multiome 990
chr14:24,113,681–24,115,917 184.9 kb Distal (>10kb) Multiome 1166
chr14:24,135,549–24,136,884 163.8 kb Distal (>10kb) Multiome 778
chr14:24,140,526–24,142,331 158.2 kb Distal (>10kb) Multiome 1034
chr14:24,146,204–24,148,108 152.5 kb Distal (>10kb) Multiome 918
chr14:24,160,877–24,161,762 138.6 kb Distal (>10kb) Multiome 970
chr14:24,171,489–24,172,698 128.0 kb Distal (>10kb) Multiome 365
chr14:24,188,229–24,189,111 111.1 kb Distal (>10kb) Multiome 1074
chr14:24,195,072–24,196,365 104.3 kb Distal (>10kb) Multiome 1059
chr14:24,212,871–24,213,884 86.5 kb Distal (>10kb) Multiome 1036
chr14:24,215,523–24,216,241 83.9 kb Distal (>10kb) Multiome 955
chr14:24,231,706–24,233,147 67.3 kb Distal (>10kb) Multiome 1027
chr14:24,241,845–24,243,572 57.3 kb Distal (>10kb) Multiome HiCAR 1077
chr14:24,270,770–24,271,924 28.5 kb Distal (>10kb) Multiome 1089
chr14:24,296,930–24,297,122 2.8 kb Proximal (<10kb) 383
chr14:24,299,120–24,300,273 101 bp At TSS Multiome 892
chr14:24,307,769–24,308,385 7.9 kb Proximal (<10kb) 594
chr14:24,315,948–24,316,753 16.5 kb Distal (>10kb) Multiome 736
chr14:24,332,251–24,333,127 32.7 kb Distal (>10kb) Multiome 740
chr14:24,366,594–24,369,358 69.2 kb Distal (>10kb) Multiome 921
chr14:24,398,424–24,399,423 99.0 kb Distal (>10kb) Multiome 354
chr14:24,429,597–24,431,070 130.2 kb Distal (>10kb) Multiome 903
chr14:24,431,554–24,432,205 132.0 kb Distal (>10kb) Multiome 604
chr14:24,441,935–24,443,373 142.7 kb Distal (>10kb) Multiome 1072
chr14:24,481,599–24,482,121 182.0 kb Distal (>10kb) Multiome 593

Genome Browser

Genomic view of the NOP9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:24,026,218 – 24,492,121
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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