Enables rRNA (cytosine-C5-)-methyltransferase activity. Involved in positive regulation of cell population proliferation; regulation of signal transduction by p53 class mediator; and ribosome biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NOP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:6,278,466–6,279,375 | 289.5 kb | Distal (>10kb) Multiome | 655 | |
| chr12:6,310,091–6,311,512 | 257.6 kb | Distal (>10kb) Multiome | 645 | |
| chr12:6,322,926–6,323,961 | 244.9 kb | Distal (>10kb) Multiome | 536 | |
| chr12:6,329,238–6,330,028 | 238.8 kb | Distal (>10kb) Multiome | 135 | |
| chr12:6,335,766–6,337,493 | 231.7 kb | Distal (>10kb) Multiome | 962 | |
| chr12:6,341,619–6,342,234 | 226.1 kb | Distal (>10kb) Multiome | 657 | |
| chr12:6,363,292–6,364,138 | 204.7 kb | Distal (>10kb) Multiome | 718 | |
| chr12:6,370,899–6,371,535 | 197.0 kb | Distal (>10kb) Multiome | 572 | |
| chr12:6,375,204–6,377,302 | 192.8 kb | Distal (>10kb) Multiome | 601 | |
| chr12:6,383,790–6,384,442 | 184.2 kb | Distal (>10kb) Multiome | 812 | |
| chr12:6,451,305–6,451,838 | 116.9 kb | Distal (>10kb) Multiome | 535 | |
| chr12:6,469,922–6,471,399 | 97.5 kb | Distal (>10kb) Multiome | 930 | |
| chr12:6,492,998–6,494,331 | 75.0 kb | Distal (>10kb) Multiome | 936 | |
| chr12:6,533,253–6,535,726 | 34.0 kb | Distal (>10kb) Multiome HiCAR | 1131 | |
| chr12:6,539,914–6,540,883 | 27.6 kb | Distal (>10kb) Multiome | 427 | |
| chr12:6,554,111–6,554,621 | 14.0 kb | Distal (>10kb) Multiome | 407 | |
| chr12:6,555,532–6,556,318 | 12.2 kb | Distal (>10kb) Multiome | 551 | |
| chr12:6,567,822–6,568,719 | 52 bp | At TSS Multiome | 837 | |
| chr12:6,570,375–6,570,554 | 2.1 kb | Proximal (<10kb) | 251 | |
| chr12:6,605,947–6,607,790 | 39.2 kb | Distal (>10kb) Multiome HiCAR | 774 | |
| chr12:6,613,155–6,614,551 | 45.8 kb | Distal (>10kb) Multiome | 810 | |
| chr12:6,620,128–6,620,868 | 52.2 kb | Distal (>10kb) Multiome | 239 | |
| chr12:6,662,802–6,663,663 | 94.9 kb | Distal (>10kb) Multiome | 868 | |
| chr12:6,688,517–6,690,027 | 121.1 kb | Distal (>10kb) Multiome | 943 | |
| chr12:6,699,959–6,700,887 | 132.1 kb | Distal (>10kb) Multiome | 263 | |
| chr12:6,723,658–6,724,773 | 155.8 kb | Distal (>10kb) Multiome | 1065 | |
| chr12:6,752,554–6,754,332 | 185.2 kb | Distal (>10kb) Multiome | 975 | |
| chr12:6,763,677–6,764,983 | 196.1 kb | Distal (>10kb) Multiome | 570 | |
| chr12:6,765,172–6,767,791 | 198.0 kb | Distal (>10kb) Multiome | 824 | |
| chr12:6,768,329–6,769,331 | 200.8 kb | Distal (>10kb) Multiome | 249 | |
| chr12:6,778,736–6,779,459 | 210.7 kb | Distal (>10kb) Multiome | 777 | |
| chr12:6,821,268–6,822,155 | 253.4 kb | Distal (>10kb) Multiome | 299 | |
| chr12:6,825,458–6,825,915 | 257.4 kb | Distal (>10kb) Multiome | 404 | |
| chr12:6,828,101–6,829,966 | 261.3 kb | Distal (>10kb) Multiome | 689 | |
| chr12:6,851,017–6,853,279 | 284.0 kb | Distal (>10kb) Multiome | 966 | |
| chr12:6,866,801–6,870,175 | 299.2 kb | Distal (>10kb) Multiome | 887 |
Genomic view of the NOP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.