NOL12

nucleolar protein 12 | MGC3731, Nop25, RRP17

Enables identical protein binding activity. Predicted to be located in cytoplasm and nucleus. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1

Biological processes 11 terms

RNA binding (GO:0003723)RNA binding (GO:0003723)cytoplasm (GO:0005737)identical protein binding (GO:0042802)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleus (GO:0005634)protein binding (GO:0005515)rRNA binding (GO:0019843)rRNA binding (GO:0019843)single-stranded DNA binding (GO:0003697)

Expression (TPM)

TFs regulating NOL12 0 TFs

Transcription factors with Perturb-seq knockdown data for NOL12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOL12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NOL12

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOL12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr22:37,419,824–37,420,580	266.1 kb	Distal (>10kb) Multiome	150
chr22:37,518,831–37,519,884	166.9 kb	Distal (>10kb) Multiome	548
chr22:37,545,569–37,546,885	140.0 kb	Distal (>10kb) Multiome	682
chr22:37,559,893–37,560,965	126.0 kb	Distal (>10kb) Multiome	589
chr22:37,569,013–37,570,549	116.9 kb	Distal (>10kb) Multiome	695
chr22:37,608,044–37,609,455	77.6 kb	Distal (>10kb) Multiome	920
chr22:37,639,157–37,639,951	46.8 kb	Distal (>10kb) Multiome	427
chr22:37,658,172–37,659,508	27.8 kb	Distal (>10kb) Multiome	722
chr22:37,674,916–37,675,641	10.9 kb	Distal (>10kb) Multiome	607
chr22:37,676,590–37,677,674	9.1 kb	Proximal (<10kb) Multiome	655
chr22:37,681,647–37,681,847	4.5 kb	Proximal (<10kb)	322
chr22:37,686,104–37,686,784	61 bp	At TSS Multiome	866
chr22:37,696,496–37,697,685	10.5 kb	Distal (>10kb) Multiome	428
chr22:37,745,641–37,746,995	59.8 kb	Distal (>10kb) Multiome	627
chr22:37,802,124–37,802,989	116.0 kb	Distal (>10kb) Multiome	603
chr22:37,804,679–37,805,768	118.9 kb	Distal (>10kb) Multiome	763
chr22:37,807,436–37,808,267	121.5 kb	Distal (>10kb) Multiome	766
chr22:37,817,672–37,819,114	131.5 kb	Distal (>10kb) Multiome	713
chr22:37,824,524–37,825,593	138.6 kb	Distal (>10kb) Multiome	173
chr22:37,843,748–37,844,743	158.0 kb	Distal (>10kb) Multiome	798
chr22:37,849,215–37,849,709	163.0 kb	Distal (>10kb) Multiome	753
chr22:37,905,849–37,906,846	219.9 kb	Distal (>10kb) Multiome	552
chr22:37,933,777–37,934,256	247.7 kb	Distal (>10kb) Multiome	679
chr22:37,953,153–37,954,120	267.3 kb	Distal (>10kb) Multiome	617
chr22:37,983,021–37,985,110	298.1 kb	Distal (>10kb) Multiome	228

Genome Browser

Genomic view of the NOL12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.