The protein encoded by this gene is a proteolipid that may be involved in the regulation of ion channels during brain development. The encoded protein may also play a role in forming and maintaining the structure of the nervous system. This gene is found within an intron of another gene, bladder cancer associated protein, but on the opposite strand. This gene is imprinted and is expressed only from the paternal allele. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for NNAT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NNAT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NNAT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:37,289,329–37,289,991 | 231.6 kb | Distal (>10kb) Multiome HiCAR | 1018 | |
| chr20:37,319,185–37,319,833 | 201.8 kb | Distal (>10kb) Multiome | 87 | |
| chr20:37,345,682–37,346,478 | 175.2 kb | Distal (>10kb) Multiome | 557 | |
| chr20:37,396,207–37,397,008 | 124.7 kb | Distal (>10kb) Multiome HiCAR | 227 | |
| chr20:37,520,318–37,521,734 | 31 bp | At TSS Multiome | 237 | |
| chr20:37,527,439–37,528,617 | 6.7 kb | Proximal (<10kb) Multiome | 899 | |
| chr20:37,564,323–37,564,876 | 43.3 kb | Distal (>10kb) Multiome | 440 | |
| chr20:37,693,635–37,694,526 | 172.7 kb | Distal (>10kb) Multiome | 809 |
Genomic view of the NNAT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.