This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Transcription factors with Perturb-seq knockdown data for NMT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NMT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NMT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:14,877,852–14,879,824 | 289.9 kb | Distal (>10kb) Multiome | 977 | |
| chr10:14,952,697–14,954,554 | 215.5 kb | Distal (>10kb) Multiome | 1101 | |
| chr10:14,959,013–14,960,243 | 209.1 kb | Distal (>10kb) Multiome | 879 | |
| chr10:15,088,358–15,089,070 | 79.9 kb | Distal (>10kb) Multiome | 622 | |
| chr10:15,096,597–15,098,027 | 71.4 kb | Distal (>10kb) Multiome | 949 | |
| chr10:15,167,406–15,169,756 | 227 bp | At TSS Multiome | 796 | |
| chr10:15,370,316–15,371,740 | 202.6 kb | Distal (>10kb) Multiome | 451 |
Genomic view of the NMT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.