Enables ribosylnicotinamide kinase activity and ribosylnicotinate kinase activity. Predicted to be involved in NAD metabolic process. Predicted to act upstream of or within negative regulation of myoblast differentiation. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for NMRK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NMRK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NMRK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:3,699,968–3,700,899 | 232.5 kb | Distal (>10kb) Multiome | 489 | |
| chr19:3,721,462–3,721,997 | 211.4 kb | Distal (>10kb) Multiome | 760 | |
| chr19:3,722,652–3,723,093 | 210.1 kb | Distal (>10kb) Multiome | 106 | |
| chr19:3,761,103–3,762,150 | 171.4 kb | Distal (>10kb) Multiome | 839 | |
| chr19:3,762,300–3,763,344 | 170.1 kb | Distal (>10kb) Multiome | 817 | |
| chr19:3,868,451–3,869,181 | 63.9 kb | Distal (>10kb) Multiome | 233 | |
| chr19:3,932,937–3,933,664 | 209 bp | At TSS Multiome | 198 | |
| chr19:3,968,623–3,969,280 | 35.8 kb | Distal (>10kb) Multiome | 547 | |
| chr19:3,970,535–3,971,713 | 38.2 kb | Distal (>10kb) Multiome | 728 | |
| chr19:3,985,032–3,985,862 | 52.4 kb | Distal (>10kb) Multiome | 932 | |
| chr19:4,006,992–4,008,553 | 74.5 kb | Distal (>10kb) Multiome | 888 | |
| chr19:4,064,058–4,067,782 | 132.9 kb | Distal (>10kb) Multiome | 811 | |
| chr19:4,123,681–4,124,581 | 191.1 kb | Distal (>10kb) Multiome | 798 | |
| chr19:4,182,102–4,182,890 | 249.5 kb | Distal (>10kb) Multiome | 862 | |
| chr19:4,198,066–4,198,600 | 265.3 kb | Distal (>10kb) Multiome | 214 |
Genomic view of the NMRK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.