This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NMNAT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NMNAT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NMNAT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:183,185,705–183,186,607 | 232.2 kb | Distal (>10kb) Multiome | 380 | |
| chr1:183,331,081–183,331,905 | 86.9 kb | Distal (>10kb) Multiome | 224 | |
| chr1:183,416,644–183,417,055 | 1.3 kb | Proximal (<10kb) | 309 | |
| chr1:183,417,152–183,417,585 | 794 bp | At TSS | 174 | |
| chr1:183,417,849–183,418,699 | 105 bp | At TSS Multiome | 267 | |
| chr1:183,471,010–183,473,189 | 53.6 kb | Distal (>10kb) Multiome | 1169 | |
| chr1:183,635,123–183,636,512 | 217.5 kb | Distal (>10kb) Multiome | 923 |
Genomic view of the NMNAT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.