Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]
Transcription factors with Perturb-seq knockdown data for NME6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NME6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NME6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:48,088,196–48,089,485 | 212.3 kb | Distal (>10kb) Multiome | 933 | |
| chr3:48,187,500–48,188,989 | 112.8 kb | Distal (>10kb) Multiome | 820 | |
| chr3:48,240,728–48,241,473 | 60.2 kb | Distal (>10kb) Multiome | 843 | |
| chr3:48,300,947–48,301,746 | 44 bp | At TSS Multiome | 954 | |
| chr3:48,372,864–48,373,543 | 71.9 kb | Distal (>10kb) Multiome HiCAR | 49 | |
| chr3:48,428,528–48,430,504 | 128.7 kb | Distal (>10kb) Multiome HiCAR | 910 | |
| chr3:48,439,801–48,440,548 | 138.8 kb | Distal (>10kb) Multiome HiCAR | 787 | |
| chr3:48,446,396–48,447,180 | 145.4 kb | Distal (>10kb) Multiome | 767 | |
| chr3:48,465,344–48,466,310 | 164.4 kb | Distal (>10kb) Multiome | 670 | |
| chr3:48,472,636–48,473,658 | 171.9 kb | Distal (>10kb) Multiome | 821 | |
| chr3:48,503,451–48,504,839 | 202.7 kb | Distal (>10kb) Multiome | 419 | |
| chr3:48,556,022–48,557,666 | 255.7 kb | Distal (>10kb) Multiome | 794 | |
| chr3:48,558,131–48,558,793 | 257.0 kb | Distal (>10kb) Multiome | 503 |
Genomic view of the NME6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.