The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for NLRX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NLRX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NLRX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:118,907,074–118,907,685 | 261.4 kb | Distal (>10kb) Multiome | 491 | |
| chr11:118,909,181–118,909,816 | 259.4 kb | Distal (>10kb) Multiome | 326 | |
| chr11:118,909,976–118,911,609 | 258.1 kb | Distal (>10kb) Multiome | 652 | |
| chr11:118,911,717–118,912,963 | 256.5 kb | Distal (>10kb) Multiome | 689 | |
| chr11:118,916,429–118,917,335 | 251.8 kb | Distal (>10kb) Multiome | 355 | |
| chr11:118,917,640–118,918,851 | 250.3 kb | Distal (>10kb) Multiome | 522 | |
| chr11:118,925,703–118,926,356 | 242.7 kb | Distal (>10kb) Multiome | 595 | |
| chr11:118,927,947–118,930,852 | 239.3 kb | Distal (>10kb) Multiome | 892 | |
| chr11:118,997,538–118,998,797 | 170.6 kb | Distal (>10kb) Multiome | 798 | |
| chr11:119,018,081–119,019,265 | 150.2 kb | Distal (>10kb) Multiome | 897 | |
| chr11:119,029,885–119,031,330 | 137.8 kb | Distal (>10kb) Multiome | 876 | |
| chr11:119,056,436–119,057,778 | 111.5 kb | Distal (>10kb) Multiome | 815 | |
| chr11:119,067,446–119,068,100 | 101.0 kb | Distal (>10kb) Multiome | 762 | |
| chr11:119,084,563–119,085,756 | 83.7 kb | Distal (>10kb) Multiome | 846 | |
| chr11:119,093,969–119,096,070 | 73.2 kb | Distal (>10kb) Multiome | 1046 | |
| chr11:119,101,351–119,102,791 | 66.6 kb | Distal (>10kb) Multiome | 871 | |
| chr11:119,106,906–119,107,993 | 61.4 kb | Distal (>10kb) Multiome | 650 | |
| chr11:119,120,857–119,122,037 | 47.3 kb | Distal (>10kb) Multiome | 787 | |
| chr11:119,144,795–119,145,355 | 23.7 kb | Distal (>10kb) Multiome | 230 | |
| chr11:119,148,816–119,149,933 | 19.2 kb | Distal (>10kb) Multiome | 262 | |
| chr11:119,168,601–119,169,645 | 169 bp | At TSS Multiome | 794 | |
| chr11:119,205,241–119,207,150 | 37.4 kb | Distal (>10kb) Multiome | 695 | |
| chr11:119,315,017–119,315,819 | 146.6 kb | Distal (>10kb) Multiome | 270 | |
| chr11:119,316,693–119,317,760 | 148.5 kb | Distal (>10kb) Multiome | 463 | |
| chr11:119,320,617–119,321,906 | 153.0 kb | Distal (>10kb) Multiome | 516 | |
| chr11:119,334,140–119,334,815 | 165.7 kb | Distal (>10kb) Multiome | 577 | |
| chr11:119,337,716–119,338,797 | 169.6 kb | Distal (>10kb) Multiome | 412 | |
| chr11:119,339,587–119,340,902 | 171.4 kb | Distal (>10kb) Multiome | 477 | |
| chr11:119,356,332–119,357,013 | 188.0 kb | Distal (>10kb) Multiome | 366 | |
| chr11:119,361,041–119,361,699 | 192.6 kb | Distal (>10kb) Multiome | 431 | |
| chr11:119,363,939–119,364,561 | 195.5 kb | Distal (>10kb) Multiome | 255 | |
| chr11:119,377,954–119,379,307 | 209.8 kb | Distal (>10kb) Multiome | 307 | |
| chr11:119,380,894–119,382,060 | 212.9 kb | Distal (>10kb) Multiome | 800 | |
| chr11:119,422,349–119,423,771 | 254.5 kb | Distal (>10kb) Multiome | 235 |
Genomic view of the NLRX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.