Predicted to be involved in regulation of Notch signaling pathway. Predicted to act upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and positive regulation of canonical Wnt signaling pathway. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NLE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NLE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NLE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:34,886,833–34,887,368 | 255.2 kb | Distal (>10kb) Multiome | 205 | |
| chr17:34,961,027–34,961,847 | 180.8 kb | Distal (>10kb) Multiome | 793 | |
| chr17:34,980,134–34,981,317 | 161.6 kb | Distal (>10kb) Multiome | 855 | |
| chr17:35,063,589–35,064,217 | 78.5 kb | Distal (>10kb) Multiome | 813 | |
| chr17:35,088,426–35,090,139 | 53.0 kb | Distal (>10kb) Multiome | 805 | |
| chr17:35,119,302–35,120,200 | 22.5 kb | Distal (>10kb) Multiome | 761 | |
| chr17:35,141,908–35,142,655 | 13 bp | At TSS Multiome | 873 | |
| chr17:35,242,191–35,243,858 | 100.6 kb | Distal (>10kb) Multiome | 590 | |
| chr17:35,312,777–35,313,483 | 170.7 kb | Distal (>10kb) Multiome | 263 | |
| chr17:35,578,257–35,578,977 | 436.3 kb | Distal (>10kb) Multiome HiCAR | 860 |
Genomic view of the NLE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.