NKAIN4 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]
Transcription factors with Perturb-seq knockdown data for NKAIN4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NKAIN4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NKAIN4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:63,006,367–63,007,246 | 265.8 kb | Distal (>10kb) Multiome | 189 | |
| chr20:63,071,594–63,072,696 | 200.7 kb | Distal (>10kb) Multiome | 246 | |
| chr20:63,178,716–63,179,743 | 93.7 kb | Distal (>10kb) Multiome | 386 | |
| chr20:63,215,706–63,216,790 | 56.4 kb | Distal (>10kb) Multiome | 965 | |
| chr20:63,272,274–63,273,137 | 76 bp | At TSS Multiome | 736 | |
| chr20:63,488,166–63,488,632 | 215.8 kb | Distal (>10kb) Multiome | 127 | |
| chr20:63,519,657–63,521,677 | 248.0 kb | Distal (>10kb) Multiome | 712 | |
| chr20:63,537,759–63,538,455 | 265.4 kb | Distal (>10kb) Multiome | 823 | |
| chr20:63,552,551–63,554,733 | 280.9 kb | Distal (>10kb) Multiome | 544 |
Genomic view of the NKAIN4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.