NKAIN1 is a member of a family of mammalian proteins with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]
Transcription factors with Perturb-seq knockdown data for NKAIN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NKAIN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NKAIN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:31,065,191–31,066,200 | 174.1 kb | Distal (>10kb) Multiome | 984 | |
| chr1:31,154,613–31,155,769 | 84.8 kb | Distal (>10kb) Multiome | 807 | |
| chr1:31,182,154–31,182,689 | 57.5 kb | Distal (>10kb) Multiome | 644 | |
| chr1:31,239,028–31,240,122 | 81 bp | At TSS Multiome | 323 | |
| chr1:31,296,477–31,297,658 | 57.0 kb | Distal (>10kb) Multiome | 749 | |
| chr1:31,372,771–31,374,054 | 133.8 kb | Distal (>10kb) Multiome | 474 | |
| chr1:31,394,503–31,395,142 | 155.0 kb | Distal (>10kb) Multiome | 592 | |
| chr1:31,412,821–31,414,256 | 173.2 kb | Distal (>10kb) Multiome | 550 |
Genomic view of the NKAIN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.