Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NIPAL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NIPAL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NIPAL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:98,011,075–98,011,541 | 282.9 kb | Distal (>10kb) Multiome | 178 | |
| chr8:98,045,232–98,046,414 | 248.4 kb | Distal (>10kb) Multiome | 829 | |
| chr8:98,064,246–98,065,195 | 229.3 kb | Distal (>10kb) Multiome | 385 | |
| chr8:98,116,581–98,117,836 | 176.9 kb | Distal (>10kb) Multiome | 829 | |
| chr8:98,169,855–98,170,713 | 123.9 kb | Distal (>10kb) Multiome HiCAR | 369 | |
| chr8:98,291,521–98,292,708 | 1.4 kb | Proximal (<10kb) | 167 | |
| chr8:98,293,197–98,294,622 | 371 bp | At TSS Multiome | 795 | |
| chr8:98,294,747–98,294,885 | 637 bp | At TSS | 65 | |
| chr8:98,426,425–98,428,258 | 132.9 kb | Distal (>10kb) Multiome | 447 |
Genomic view of the NIPAL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.