The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009]
Transcription factors with Perturb-seq knockdown data for NINJ1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NINJ1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NINJ1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:92,877,587–92,878,337 | 256.2 kb | Distal (>10kb) Multiome | 591 | |
| chr9:93,058,154–93,059,241 | 75.6 kb | Distal (>10kb) Multiome | 417 | |
| chr9:93,094,880–93,097,281 | 38.3 kb | Distal (>10kb) Multiome | 813 | |
| chr9:93,133,298–93,134,791 | 40 bp | At TSS Multiome | 796 | |
| chr9:93,159,802–93,160,270 | 25.9 kb | Distal (>10kb) Multiome | 500 | |
| chr9:93,183,782–93,185,608 | 49.9 kb | Distal (>10kb) Multiome | 401 | |
| chr9:93,346,091–93,346,711 | 212.0 kb | Distal (>10kb) Multiome | 137 | |
| chr9:93,364,969–93,366,461 | 231.5 kb | Distal (>10kb) Multiome | 123 |
Genomic view of the NINJ1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.