This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NIN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NIN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NIN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:50,531,734–50,533,317 | 298.5 kb | Distal (>10kb) Multiome | 905 | |
| chr14:50,559,970–50,561,283 | 270.6 kb | Distal (>10kb) Multiome | 524 | |
| chr14:50,667,319–50,668,903 | 162.9 kb | Distal (>10kb) Multiome | 914 | |
| chr14:50,823,525–50,824,353 | 7.2 kb | Proximal (<10kb) Multiome | 183 | |
| chr14:50,825,065–50,825,262 | 5.9 kb | Proximal (<10kb) | 10 | |
| chr14:50,829,783–50,831,951 | 34 bp | At TSS Multiome | 634 | |
| chr14:50,871,977–50,872,487 | 41.0 kb | Distal (>10kb) Multiome | 114 | |
| chr14:50,943,178–50,945,258 | 113.4 kb | Distal (>10kb) Multiome | 823 | |
| chr14:51,093,327–51,096,214 | 264.1 kb | Distal (>10kb) Multiome | 700 |
Genomic view of the NIN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.