This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NGB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NGB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NGB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:76,987,872–76,988,397 | 283.1 kb | Distal (>10kb) Multiome | 38 | |
| chr14:77,024,027–77,024,710 | 246.8 kb | Distal (>10kb) Multiome | 368 | |
| chr14:77,025,547–77,029,182 | 242.4 kb | Distal (>10kb) Multiome | 996 | |
| chr14:77,032,573–77,034,628 | 237.2 kb | Distal (>10kb) Multiome | 917 | |
| chr14:77,040,063–77,040,913 | 230.7 kb | Distal (>10kb) Multiome | 765 | |
| chr14:77,085,220–77,085,934 | 185.6 kb | Distal (>10kb) Multiome | 132 | |
| chr14:77,088,297–77,088,792 | 182.8 kb | Distal (>10kb) Multiome | 234 | |
| chr14:77,097,312–77,099,236 | 173.1 kb | Distal (>10kb) Multiome | 948 | |
| chr14:77,124,505–77,125,759 | 146.2 kb | Distal (>10kb) Multiome | 289 | |
| chr14:77,139,459–77,142,559 | 131.4 kb | Distal (>10kb) Multiome HiCAR | 507 | |
| chr14:77,181,185–77,182,207 | 89.5 kb | Distal (>10kb) Multiome | 485 | |
| chr14:77,270,588–77,271,586 | 83 bp | At TSS Multiome | 147 | |
| chr14:77,320,198–77,322,121 | 49.9 kb | Distal (>10kb) Multiome | 915 | |
| chr14:77,376,423–77,377,683 | 105.9 kb | Distal (>10kb) Multiome | 630 | |
| chr14:77,456,961–77,458,831 | 186.5 kb | Distal (>10kb) Multiome | 878 | |
| chr14:77,498,012–77,499,509 | 227.7 kb | Distal (>10kb) Multiome | 599 |
Genomic view of the NGB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.