NFKBIL1

NFKB inhibitor like 1 | IKBL, NFKBIL

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Biological processes 15 terms

cellular response to lipopolysaccharide (GO:0071222)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)negative regulation of signal transduction (GO:0009968)negative regulation of toll-like receptor signaling pathway (GO:0034122)negative regulation of toll-like receptor signaling pathway (GO:0034122)negative regulation of tumor necrosis factor production (GO:0032720)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of gene expression (GO:0010468)transcription regulator inhibitor activity (GO:0140416)

Expression (TPM)

TFs regulating NFKBIL1 0 TFs

Transcription factors with Perturb-seq knockdown data for NFKBIL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFKBIL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NFKBIL1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFKBIL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:31,307,823–31,308,922	239.4 kb	Distal (>10kb) Multiome	248
chr6:31,366,884–31,367,398	180.5 kb	Distal (>10kb) Multiome	433
chr6:31,399,631–31,400,231	147.8 kb	Distal (>10kb) Multiome	678
chr6:31,403,046–31,404,269	144.0 kb	Distal (>10kb) Multiome	796
chr6:31,441,682–31,442,105	105.8 kb	Distal (>10kb) Multiome	316
chr6:31,462,703–31,463,323	84.5 kb	Distal (>10kb) Multiome	352
chr6:31,497,638–31,498,615	49.6 kb	Distal (>10kb) Multiome	613
chr6:31,541,205–31,542,816	5.5 kb	Proximal (<10kb) Multiome	1073
chr6:31,546,485–31,547,136	844 bp	At TSS Multiome	589
chr6:31,547,301–31,547,742	28 bp	At TSS Multiome	762
chr6:31,580,713–31,581,330	33.4 kb	Distal (>10kb) Multiome HiCAR	745
chr6:31,619,744–31,621,435	72.9 kb	Distal (>10kb) Multiome HiCAR	1127
chr6:31,651,682–31,653,297	105.1 kb	Distal (>10kb) Multiome	1113
chr6:31,660,325–31,660,941	113.2 kb	Distal (>10kb) Multiome	892
chr6:31,664,725–31,666,373	117.3 kb	Distal (>10kb) Multiome	1039
chr6:31,682,887–31,683,880	135.7 kb	Distal (>10kb) Multiome	248
chr6:31,702,816–31,703,520	155.7 kb	Distal (>10kb) Multiome	875
chr6:31,713,576–31,714,641	166.5 kb	Distal (>10kb) Multiome	171
chr6:31,728,852–31,730,814	182.6 kb	Distal (>10kb) Multiome	979
chr6:31,739,236–31,740,741	192.3 kb	Distal (>10kb) Multiome	1043
chr6:31,766,045–31,766,778	218.9 kb	Distal (>10kb) Multiome	351
chr6:31,795,097–31,796,366	248.3 kb	Distal (>10kb) Multiome	979
chr6:31,806,162–31,807,183	259.4 kb	Distal (>10kb) Multiome	947
chr6:31,814,125–31,815,936	267.0 kb	Distal (>10kb) Multiome	822
chr6:31,818,020–31,818,663	270.8 kb	Distal (>10kb) Multiome	280
chr6:31,821,306–31,822,544	274.4 kb	Distal (>10kb) Multiome	714
chr6:31,826,770–31,828,135	279.9 kb	Distal (>10kb) Multiome	1000
chr6:31,834,277–31,835,371	287.1 kb	Distal (>10kb) Multiome	1085

Genome Browser

Genomic view of the NFKBIL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.