This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]
Transcription factors with Perturb-seq knockdown data for NFASC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFASC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFASC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:204,565,653–204,566,244 | 262.7 kb | Distal (>10kb) Multiome | 403 | |
| chr1:204,684,550–204,685,936 | 143.2 kb | Distal (>10kb) Multiome | 313 | |
| chr1:204,714,466–204,715,865 | 113.6 kb | Distal (>10kb) Multiome | 356 | |
| chr1:204,806,979–204,807,672 | 21.4 kb | Distal (>10kb) Multiome | 641 | |
| chr1:204,828,302–204,828,945 | 7 bp | At TSS Multiome | 287 | |
| chr1:204,837,560–204,837,711 | 8.9 kb | Proximal (<10kb) | 250 | |
| chr1:204,920,575–204,920,925 | 8.5 kb | Proximal (<10kb) | 59 | |
| chr1:204,923,251–204,924,645 | 95.7 kb | Distal (>10kb) Multiome HiCAR | 297 | |
| chr1:204,927,214–204,930,121 | 100.6 kb | Distal (>10kb) Multiome HiCAR | 387 | |
| chr1:204,991,288–204,991,881 | 162.9 kb | Distal (>10kb) Multiome | 157 | |
| chr1:205,121,687–205,122,681 | 293.5 kb | Distal (>10kb) Multiome | 1123 |
Genomic view of the NFASC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.