This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for NEURL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEURL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEURL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:45,764,655–45,765,666 | 125.4 kb | Distal (>10kb) Multiome | 192 | |
| chr20:45,770,709–45,771,657 | 119.2 kb | Distal (>10kb) Multiome | 436 | |
| chr20:45,791,633–45,792,259 | 98.5 kb | Distal (>10kb) Multiome | 882 | |
| chr20:45,812,087–45,813,052 | 78.0 kb | Distal (>10kb) Multiome | 695 | |
| chr20:45,833,493–45,834,622 | 56.5 kb | Distal (>10kb) Multiome | 833 | |
| chr20:45,856,871–45,858,137 | 33.0 kb | Distal (>10kb) Multiome | 884 | |
| chr20:45,880,796–45,881,524 | 9.3 kb | Proximal (<10kb) Multiome | 738 | |
| chr20:45,890,127–45,891,800 | 890 bp | At TSS Multiome | 1095 | |
| chr20:45,910,538–45,912,397 | 21.8 kb | Distal (>10kb) Multiome | 713 | |
| chr20:45,933,591–45,935,780 | 44.6 kb | Distal (>10kb) Multiome | 1195 | |
| chr20:45,971,553–45,972,790 | 81.7 kb | Distal (>10kb) Multiome | 1206 | |
| chr20:46,004,647–46,005,315 | 114.5 kb | Distal (>10kb) Multiome | 207 | |
| chr20:46,011,604–46,012,166 | 121.4 kb | Distal (>10kb) Multiome | 239 | |
| chr20:46,013,565–46,014,586 | 123.6 kb | Distal (>10kb) Multiome | 735 | |
| chr20:46,021,209–46,023,166 | 131.5 kb | Distal (>10kb) Multiome | 679 | |
| chr20:46,031,750–46,032,261 | 141.6 kb | Distal (>10kb) Multiome | 227 | |
| chr20:46,058,408–46,058,983 | 168.3 kb | Distal (>10kb) Multiome | 123 | |
| chr20:46,089,092–46,090,355 | 199.4 kb | Distal (>10kb) Multiome | 1047 | |
| chr20:46,091,736–46,092,300 | 201.7 kb | Distal (>10kb) Multiome | 38 | |
| chr20:46,117,897–46,118,755 | 227.8 kb | Distal (>10kb) Multiome | 376 | |
| chr20:46,174,457–46,175,011 | 284.2 kb | Distal (>10kb) Multiome | 277 |
Genomic view of the NEURL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.