This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NEU3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEU3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEU3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:74,731,155–74,731,658 | 257.5 kb | Distal (>10kb) Multiome | 131 | |
| chr11:74,748,226–74,749,731 | 240.1 kb | Distal (>10kb) Multiome | 854 | |
| chr11:74,948,631–74,949,595 | 39.7 kb | Distal (>10kb) Multiome | 870 | |
| chr11:74,988,546–74,989,331 | 98 bp | At TSS Multiome | 661 | |
| chr11:74,991,061–74,991,289 | 2.1 kb | Proximal (<10kb) | 42 | |
| chr11:75,240,428–75,242,358 | 252.8 kb | Distal (>10kb) Multiome | 618 |
Genomic view of the NEU3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.